What is Lortab? Lortab is a composition of acetaminophen and hydrocodone that are pain relievers. However, Hydrocodone is a form of Narcotic as it is an opioid pain medication. Acetaminophen on the other hand is less effective as a pain reliever and enhances the impact of hydrocodone. Lortab is a common pain reliever which helps… Continue reading How long does Lortab stay in your system?